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dc.rights.licenseAl consultar y hacer uso de este recurso, está aceptando las condiciones de uso establecidas por los autores.es_CO
dc.contributor.advisorZimmermann, Barbara Hanna
dc.contributor.advisorMorizono, Hiroki
dc.contributor.advisorGaravito Aguilar, Zayra Viviana 
dc.contributor.authorLópez Moreno, Andrea Johana
dc.coverage.spatialBogotáes_CO
dc.date.accessioned2018-09-28T10:34:15Z
dc.date.available2018-09-28T10:34:15Z
dc.date.issued2015es_CO
dc.identifier.urihttp://hdl.handle.net/1992/13345
dc.descriptionilustracioneses_CO
dc.descriptionIncluye referencias bibliográficases_CO
dc.descriptiontextoes_CO
dc.descriptioncomputadoraes_CO
dc.descriptionrecurso en líneaes_CO
dc.description.abstractToxoplasma gondii is a ubiquitous intracellular parasite with worldwide distribution. New antiparasitic drugs with greater effectiveness in controlling T. gondii are necessary. The enzymes of de novo pyrimidine biosynthetic pathway are considered potential drug targets, because they are required for the parasite' s virulence and survival. Cytidine triphosphate synthase (CTPase) catalyzes the conversion of UTP to CTP, the final step in the production of cytidine nucleotides, and the first step in the formation of phospholipid intermediates. In many organisms, CTPase also plays a structural role in vivo, forming filaments together with other proteins. The function of these filaments is unknown, and identification of their protein components could aid in elucidating function. Our goal was the biochemical characterization of cytidine triphosphate synthase of T. gondii (TgCTPase), and generated tools to study protein-protein interactions, in order to begin to determine its importance as a potential antiparasitic targetes_CO
dc.format.extent1 recurso en línea (61 hojas)es_CO
dc.format.mediumarchivo de textoes_CO
dc.language.isoenges_CO
dc.publisherUniandeses_CO
dc.sourceinstname:Universidad de los Andeses_CO
dc.sourcereponame:Sénecaes_CO
dc.titleBiochemical characterization of cytidine triphosphate synthase (CTPase) from Toxoplasma gondiies_CO
dc.typemasterThesises_CO
dc.publisher.programMaestría en Ciencias Biológicases_CO
dc.rights.accessRightsopenAccess
dc.subject.keywordToxoplasma gondii - Investigacioneses_CO
dc.subject.keywordInteracciones proteína-proteína - Investigacioneses_CO
dc.creator.degreeTesis (Magíster en Ciencias Biológicas) -- Universidad de los Andeses_CO
dc.identifier.urlhttp://biblioteca.uniandes.edu.co/acepto201699.php?id=7962.pdfes_CO
dc.publisher.facultyFacultad de Cienciases_CO
dc.publisher.departmentDepartamento de Biologíaes_CO
dc.type.versionpublishedVersion


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