Show simple item record

dc.rights.licenseAl consultar y hacer uso de este recurso, está aceptando las condiciones de uso establecidas por los autores.es_CO
dc.contributor.advisorCordovez Alvarez, Juan Manuel
dc.contributor.advisorPutnam, Robert W
dc.contributor.advisorToporikova, Natalia
dc.contributor.advisorValderrama Manrique, Mario Andrés 
dc.contributor.advisorHartzler, Lynn
dc.contributor.authorQuintero Escobar, María Carolina
dc.date.accessioned2018-09-27T16:36:45Z
dc.date.available2018-09-27T16:36:45Z
dc.date.issued2016
dc.identifier.urihttp://hdl.handle.net/1992/7711
dc.description.abstractThe aim of this work was to investigate intrinsic mechanisms of activation and inhibition of the C02 response in central chemoreceptors. We employed computational single neuron modeling to simulate the basic electrochemical behavior of individual chemoreceptors from the brainstem. The single-neuron model was developed following a Hodgkin-Huxley formulation characterized by a set of eleven mammalian C02/H+-sensitive ion currents: a voltage-sensitive Na+ current (INa), three Ca2+ currents (IL, IN, IT), inward and delayed rectifier K+ (Iir, Idr), two additional K+ currents (IA, IM), two Ca2+-sensitive K+ currents (ISK, IBK), and a hyperpolarization activated current (IH). We used the model to (i) simulate the general electrophysiological behavior of spontaneous chemosensitive neurons and their response to hypercapnic acidotic stimuli, (ii) to compute firing frequencies in response to different acidotic conditions, (iii) to study the effect of each ionic current on the firing rate, and (iv) to establish the role of the currents on the chemosensitive response. The results of this model give insights into the cellular mechanisms acting together to activate and modulate the C02/H* response of central chemoreceptors and argue in favor of additional braking pathways limiting the firing frequency by means of Ca2+-sensitive K+ current activationes_CO
dc.formatapplication/pdfes_CO
dc.format.extent79 hojases_CO
dc.language.isospaes_CO
dc.publisherUniandeses_CO
dc.sourceinstname:Universidad de los Andeses_CO
dc.sourcereponame:Repositorio Institucional Sénecaes_CO
dc.titleTheoretical perspectives on central chemoreception - intrinsic excitation-inhibition mechanisms in brainstem chemoreceptorses_CO
dc.typedoctoralThesises_CO
dc.publisher.programDoctorado en Ingenieríaes_CO
dc.rights.accessRightsopenAccess
dc.subject.keywordTronco cerebral - Investigaciones - Simulación por computadores_CO
dc.subject.keywordQuimiorreceptores - Investigaciones - Simulación por computadores_CO
dc.subject.keywordQuimiorrecepción - Investigaciones - Simulación por computadores_CO
dc.subject.keywordDióxido de carbono - Efectos fisiológicos - Investigaciones - Simulación por computadores_CO
dc.publisher.facultyFacultad de Ingenieríaes_CO
dc.type.versionpublishedVersion
dc.description.degreenameDoctor en Ingenieríaes_CO
dc.description.degreelevelDoctoradoes_CO


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record