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dc.rights.licenseAl consultar y hacer uso de este recurso, está aceptando las condiciones de uso establecidas por los autores.es_CO
dc.contributor.advisorBriceño Triana, Juan Carlos 
dc.contributor.advisorCabrales, Pedro
dc.contributor.advisorCordovez Alvarez, Juan Manuel
dc.contributor.advisorRincón, Ismael
dc.contributor.advisorDuperly Sánchez, John 
dc.contributor.authorCrump Lombana, Julián Guillermo
dc.date.accessioned2018-09-27T16:37:06Z
dc.date.available2018-09-27T16:37:06Z
dc.date.issued2016
dc.identifier.urihttp://hdl.handle.net/1992/7727
dc.description.abstractNitric oxide (NO) production is impaired after hemorrhagic shock (HS) due to reduced vascular endothelial shear stress (SS); uncoupling of endothelial NO synthase (eNOS) and hypoxia. We propose to supplement NO during resuscitation, using NO releasing nanoparticles (NO-np) and inhaled NO. Preliminary hemorrhagic shock and resuscitation studies, using Golden Syrian hamsters showed that NO therapies (NO-np at 5 mg/kg, 10 mg/kg, 15 mg/kg, 20 mg/kg and 40 mg/kg and inhaled NO at 89 ppm and 189 ppm) improved systemic and microcirculatory hemodynamic parameters, being the 15 mg/kg NO-np therapy superior. Subsequent 8-day survival tests where developed showing superior decisive results when compared to conventional fluid resuscitation therapies. Afterwards, an animal scale up swine model was instrumented with a Swan Ganz catheter to monitor systemic hemodynamics as mean arterial pressure (MAP), heart rate (HR), cardiac output (CO), and pulmonary artery pressures and blood chemistry. HS was induced in the swine model by withdrawing 50% of the animal's blood volume (BV) in 10 mins, HS was maintained for 60 mins, and then animals were resuscitated with 50% of the shed volume of Voluven@ (HES) containing 15 mg/kg of NO-npes_CO
dc.formatapplication/pdfes_CO
dc.format.extent211 hojases_CO
dc.language.isoenges_CO
dc.publisherUniandeses_CO
dc.sourceinstname:Universidad de los Andeses_CO
dc.sourcereponame:Repositorio Institucional Sénecaes_CO
dc.titleThe effect of nitric oxide supplementation therapies in the hemodynamic response and outcome during hemorrhagic shock in an animal modeles_CO
dc.typedoctoralThesises_CO
dc.publisher.programDoctorado en Ingenieríaes_CO
dc.rights.accessRightsopenAccess
dc.subject.keywordChoque hermorrágico - Tratamiento - Investigacioneses_CO
dc.subject.keywordOxido nítrico - Investigacioneses_CO
dc.subject.keywordNanotecnología - Investigacioneses_CO
dc.subject.keywordHemodinámica - Investigacioneses_CO
dc.publisher.facultyFacultad de Ingenieríaes_CO
dc.type.versionpublishedVersion
dc.description.degreenameDoctor en Ingenieríaes_CO
dc.description.degreelevelDoctoradoes_CO


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