Risk assessment in occupationally exposed populations to toxic agents - determination of genetic and epigenetic effects under oxidative stress conditions

Abstract

"The research question of this thesis was: if DNA effects induced by OS associated with occupational exposure, could be used as biomarkers for early detection of high cost labor associated diseases. To address this question, the aim of the study was to characterize genetic and epigenetic effects of occupational exposure to coal dust and to Hg in mining activities. The data collected Will contribute to draw a perspective of contamination levels and to size effects of exposure. These results may help to establish health regulations focused on prevention, and to justify environmental policies in order to reduce the impact of exposure on Colombian miners' health..."-- Tomado de la introducción